Principal Design Engineer (Mechanical / Mechatronic)
Boston, Massachusetts
Experience: 10
Category: Scientific & Clinical
Contractor Work Model: Onsite
Brand: System One
Job ID: 381279
Date Posted: 10/01/2026
Shortcut: http://jobs.systemone.com/csAssp
Job Title: Principal Design Engineer (Mechanical / Mechatronic)
Location: Boston, MA
Type: Contract to Hire
Compensation: $73.08 an hour
Work Model: Onsite – onsite
Hours: Standard business hours
Security Clearance: Not specified
Overview: Join a growing U.S. biotechnology organization that supports a federal initiative in next-generation RNA medicine manufacturing. In this role, you will work alongside the Principal Design Engineer as the design authority for the machine hardware and lead designer for the highest-risk mechanical subsystem
Responsibilities
• The preliminary system design: block diagram, machine layout, modularisation and integration strategy.
• Detailed design of the system subsystems as scoped and defined by the team, including interfaces, fluid flow management, actuation mechanisms, force and displacement profiles, materials compatibility.
• Detailed design of automated liquid and sample handling: bulk reagent routing, sample presentation to analytical interfaces, product management from transcription and encapsulation through to fill-finish handoff, with aseptic continuity across every fluid-path boundary.
• The consolidated engineering design package: CAD models, 2D manufacturing drawings, bill of materials, assembly plans, and the embedded risk register.
• Fabrication, assembly, and verification of the subsystems you designed.
Requirements
• BS or MS in mechanical, mechatronic, or biomedical engineering.
• Ten or more years designing precision electromechanical instruments or automated production equipment, with at least five as lead or principal designer on products that reached build and qualification.
• Expert CAD, geometric dimensioning and tolerancing, tolerance stack-up analysis, materials selection for fluid contact and biocompatibility, and design for manufacture and assembly.
• Deep practical experience of precision fluid handling: pumps, valves, manifolds, tubing sets, connectors, seals, dead-volume and carryover control.
• A portfolio of machines that were built, not only drawn.
System One, and its subsidiaries including Joulé and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.
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