Immunology Scientist

Massachusetts, MA

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Type: Contract

Experience: 0

Category: Scientific & Clinical

Contractor Work Model: Onsite

Brand: Joulé

Shift: On-Site

Job ID: 344954

Date Posted: 01/13/2026

Shortcut: http://jobs.systemone.com/IcbgIk


Job Title: Immunology Scientist
Location: Cambridge, MA
Hours/Schedule: Monday–Friday, 8 am to 5 pm
Type: Contract (6 months)

Overview

The Scientist will join the Systems Immunology Lab within an Inflammation & Immunology research unit to generate large-scale single-cell perturbational datasets. This role focuses on functional genomics and single-cell transcriptomics, working hands-on at the bench and collaborating closely with a small, multidisciplinary research team.

Responsibilities

  • Generate custom lentiviral libraries and maintain large-scale cell cultures.

  • Produce edited cell pools using lentiviral transduction and arrayed electroporation.

  • Develop, optimize, and customize protocols to support diverse cell lines and cell types at scale.

  • Generate single-cell datasets using commercial workflows, including 10x Genomics platforms.

  • Perform standard molecular biology and cell-based assays to support functional genomics studies.

  • Collaborate with multidisciplinary experimental teams on a per-project basis.

  • Document experimental procedures, results, and observations in accordance with laboratory standards.

Qualifications

Must Have

  • Bachelor’s or Master’s degree in Biology, Immunology, or a related scientific field.

  • 3+ years of hands-on laboratory experience.

  • Strong experience with cell culture techniques, including primary immune cell handling, isolation, and in vitro stimulation.

  • Experience maintaining cell lines and working with large-scale cultures.

  • Hands-on experience with molecular biology techniques, including lentiviral infection, qPCR, western blotting, and flow cytometry.

  • Ability to perform routine bench work, including pipetting and lifting items up to approximately 10 lbs.

Nice to Have

  • Direct experience with pooled cell screening approaches such as CRISPRi, CRISPRa, or other in vitro gene-editing methods.

  • Experience generating or working with single-cell transcriptomics data.

Benefits

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.



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