Immunology Scientist
Massachusetts, MA
Experience: 0
Category: Scientific & Clinical
Contractor Work Model: Onsite
Brand: Joulé
Shift: On-Site
Job ID: 344954
Date Posted: 01/13/2026
Shortcut: http://jobs.systemone.com/IcbgIk
Job Title: Immunology Scientist
Location: Cambridge, MA
Hours/Schedule: Monday–Friday, 8 am to 5 pm
Type: Contract (6 months)
Overview
The Scientist will join the Systems Immunology Lab within an Inflammation & Immunology research unit to generate large-scale single-cell perturbational datasets. This role focuses on functional genomics and single-cell transcriptomics, working hands-on at the bench and collaborating closely with a small, multidisciplinary research team.
Responsibilities
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Generate custom lentiviral libraries and maintain large-scale cell cultures.
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Produce edited cell pools using lentiviral transduction and arrayed electroporation.
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Develop, optimize, and customize protocols to support diverse cell lines and cell types at scale.
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Generate single-cell datasets using commercial workflows, including 10x Genomics platforms.
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Perform standard molecular biology and cell-based assays to support functional genomics studies.
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Collaborate with multidisciplinary experimental teams on a per-project basis.
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Document experimental procedures, results, and observations in accordance with laboratory standards.
Qualifications
Must Have
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Bachelor’s or Master’s degree in Biology, Immunology, or a related scientific field.
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3+ years of hands-on laboratory experience.
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Strong experience with cell culture techniques, including primary immune cell handling, isolation, and in vitro stimulation.
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Experience maintaining cell lines and working with large-scale cultures.
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Hands-on experience with molecular biology techniques, including lentiviral infection, qPCR, western blotting, and flow cytometry.
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Ability to perform routine bench work, including pipetting and lifting items up to approximately 10 lbs.
Nice to Have
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Direct experience with pooled cell screening approaches such as CRISPRi, CRISPRa, or other in vitro gene-editing methods.
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Experience generating or working with single-cell transcriptomics data.
Benefits
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
Ref: #558-Scientific
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