Senior Scientist I - Computational Biologist
Rockville, MD
Experience: 0
Category: Scientific & Clinical
Contractor Work Model: Undecided
Brand: Joulé
Shift: On-Site
Job ID: 344832
Date Posted: 01/13/2026
Shortcut: http://jobs.systemone.com/IkIfsc
Job Title: Senior Scientist, Computational Biology- Antibody Engineering
Location: Rockville, MD (100% Onsite)
Hours/Schedule: Monday–Friday, 9:00 AM – 5:00 PM
Compensation: $45.00 – $70.00/hour
Type: Contract (6 months, extension possible but not guaranteed)
Overview
Leading biotechnology organization focused on cancer therapeutics is seeking a Senior Scientist, Computational Biology to support next-generation antibody discovery. This is a highly impactful, first-of-its-kind role within the organization, working at the intersection of structural biology, computational modeling, and AI-enabled protein engineering.
Responsibilities
- Develop and apply computational methods to engineer monoclonal and bispecific antibodies (90% computational/10% bench work)
- Integrate deep-learning and physics-based models for protein structure prediction and developability assessment
- Analyze structural biology and NGS datasets to guide antibody library design and optimization
- Build and maintain Python-based bioinformatics and machine learning workflows for data processing and modeling
- Collaborate closely with experimental scientists to translate computational insights into actionable design decisions
- Perform limited bench-based molecular biology work, including cloning and experimental support (up to 10%)
Requirements
- Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Sciences, Computational Biology, Bioengineering, Machine Learning, Computer Science, or related field with 0–3 years postdoctoral experience OR; Master’s degree with 5+ years of relevant industry experience
- Strong background in structural biology, including peer-reviewed publications
- Hands-on experience with protein modeling and structure prediction tools such as AlphaFold, RosettaFold, Schrödinger, MOE, or RFdiffusion
- Advanced Python programming skills for data analysis, automation, and ML workflow integration
- Experience with NGS data analysis and bioinformatics pipelines
- Familiarity with AI/ML approaches in protein engineering preferred but not required if structural biology and Python expertise are strong
- Ability to work effectively in highly collaborative, interdisciplinary research teams
- Must be legally authorized to work in the United States for any employer
Benefits
System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.
#M-3
#LI-MM1
#DI-
Ref: #558-Scientific
-
Scientist, Antibody Engineering
Rockville, MD
Job Title: Scientist – Antibody Engineering Location: Rockville, MD (Onsite) Hours/Schedule: Monday–Friday, core hours 8:00 AM – 5:00 PM (some flexibility) Compensation: $32-$40/hour Type: Contract (6 months) with potential for extension Overview Leadi...
Date Posted: 01/08/2026 Recommended
-
Immunology Scientist
Massachusetts, MA
Job Title: Immunology Scientist Location: Cambridge, MA Hours/Schedule: Monday–Friday, 8 am to 5 pm Type: Contract (6 months) Overview The Scientist will join the Systems Immunology Lab within an Inflammation & Immunology research unit to generate larg...
Date Posted: 01/13/2026 Recommended
-
Senior Civil/Structural Engineer
Lake Mary, FL
Job Title: Senior Civil/Structural Engineer Location: Lake Mary, FL Type: Direct Hire Compensation: $115000 - $135000 annually Overview A leading engineering organization is seeking a highly skilled Senior Civil and Structural Engineer to take ownershi...
Date Posted: 11/19/2025 Recommended
-
Sr Structural Designer
Cannonsburg, PA
Job Title: Civil / Structural Senior Designer Position Overview We are seeking an experienced Civil / Structural Senior Designer to join our engineering team. This role involves leading complex design and drafting projects, creating detailed 2D and 3D ...
Date Posted: 11/07/2025 Recommended
-
Structural Designer or Drafter
Cannonsburg, PA
Job Title Civil / Structural Designer / Drafter (Junior, Mid-Level, Senior, Lead) Position Overview We are seeking Civil / Structural Designers and Drafters at multiple experience levels to join our growing engineering team. These roles support a wide ...
Date Posted: 01/05/2026 Recommended
-
In Vitro Scientist II
Ridgefield, CT
Job Title: In Vitro Scientist II Location: Ridgefield Type: Contract Overview Global Pharma company looking to hire experienced Scientist to join their growing team. Must bring a Master’s Degree or Bachelor’s Degree with 3+ years experience in molecula...
Date Posted: 01/12/2026 Recommended
-
Scientist
Quincy, MA
Title: Food Scientist Location: Quincy MA Schedule: M-F 8-5 onsite daily Will accept relocation candidates Salary: up to $112k Start ASAP Education: BS/MS/PhD in Food Science/Engineering/related science or engineering field Requirements: 4+ years of ex...
Date Posted: 12/16/2025 Recommended
-
Joint Use Analyst
New Gloucester, ME
Mountain Ltd. is seeking a Joint Use Analyst to join our team remotely! Since 1979, Mountain Ltd. has successfully created and supported turnkey engineering solutions for traditional and wireless telecom providers across the United States. We are a nat...
Date Posted: 11/21/2025 Recommended
-
Fleet Risk Lead Engineer
Lake Mary, FL
Fleet Risk Lead Engineer Lake Mary, FL Type: Direct Hire Contractor Work Model: Onsite SUMMARY The Fleet Risk Senior Engineer supports the development and execution of the Fleet Risk Management Program, which identifies and mitigates emerging risks wit...
Date Posted: 12/19/2025 Recommended
-
Materials Engineer
Bellevue, WA
Job Title: Materials Engineer Location: Bellevue, WA & Everett, WA Type: Contract Compensation: $52 - $85 hourly Contractor Work Model: Onsite We are seeking a Materials Engineer (level to be determined based upon qualifications – Engineer, Senior Engi...
Date Posted: 12/15/2025 Recommended
-
Nuclear Mechanical Design Engineer
Bellevue, Washington
Job Title: Senior Mechanical Design Engineer Location: Remote Pay Range: $52–$85/hour Overview: System One is seeking a highly motivated and resourceful Senior Mechanical Design Engineer to support the conceptual and preliminary design development of v...
Date Posted: 11/03/2025 Recommended
-
Senior Piping Designer
Cannonsburg, Pennsylvania
Job Title: Senior Piping Designer Location: Canonsburg, PA Type: Direct Hire Contractor Work Model: Onsite Hours: 1st shift Senior Piping Designer (Plant 3D) Objective We are seeking an experienced Piping Designer to lead the development of intricate 3...
Date Posted: 12/26/2025 Recommended
-
(CW) Data Scientist
Novato, CA
Job Title: Data Scientist, RBQM (Clinical Trials) Location: Novato, CA Hours/Schedule: Monday–Friday, 8 am to 5 pm Compensation: $72.00–$79.00 hourly, DOQ Type: Contract **We cannot work C2C with any other agency - must be US based** Overview The Data ...
Date Posted: 01/12/2026 Recommended
-
Senior Project Engineer - Roadway
Cranberry Township , Pennsylvania
Job Title: Licensed PE Roadway Engineer Location: Pittsburg, PA (Hybrid/Remote options available) Job Type: Full-Time Job Description: We are seeking an experienced Licensed PE Roadway Engineer with 8 to 15 years of experience in roadway design, partic...
Date Posted: 10/27/2025 Recommended
-
Bridge Engineer
Cranberry Township, Pennsylvania
Job Title: Senior Bridge Engineer Location: Pittsburgh, PA (Hybrid/Onsite options available) Type: Full-Time About the Role: We are seeking an experienced Bridge Engineer (PE) with approximately 10 years of experience in structural design and transport...
Date Posted: 12/31/2025 Recommended
-
Senior Bridge Engineer Manager - FL Locations or Remote Options
Orlando, Florida
Job Title: Senior Engineering Manager (Bridge) Locations: Tampa, Orlando, Jacksonville, Palm Beach Gardens or Remote Options. Job Description: A leading engineering firm is seeking a technically diversified Senior Engineering Manager to lead and expand...
Date Posted: 11/26/2025 Recommended
-
Senior Bridge Engineer Manager - FL Locations or Remote Options
Palm Beach Gardens, Florida
Job Title: Senior Engineering Manager (Bridge) Locations: Tampa, Orlando, Jacksonville, Palm Beach Gardens or Remote Options. Job Description: A leading engineering firm is seeking a technically diversified Senior Engineering Manager to lead and expand...
Date Posted: 11/03/2025 Recommended
-
Senior Bridge Engineer Manager - FL Locations or Remote Options
Tallahassee, Florida
Job Title: Senior Engineering Manager (Bridge) Location: Tampa, Orlando, Jacksonville, Palm Beach or Remote Options Job Description: A leading engineering firm is seeking a technically diversified Senior Engineering Manager to lead and expand its Trans...
Date Posted: 11/03/2025 Recommended
-
Civil/Structural Engineer I
Lake Mary, FL
Job Title: Civil/Structural Engineer I Location: Lake Mary, FL Type: Direct Hire Compensation: $60000 - $85000 annually Work Model: Onsite Overview A leading engineering and technology organization is seeking a motivated Civil / Structural Engineer I t...
Date Posted: 11/19/2025 Recommended
-
Construction Estimator
McMurray, PA
Senior Estimator Location: McMurray, PA Employment Type: Direct Hire Salary Range: $100,000 – $150,000 Position Overview System One is seeking a Senior Estimator to lead and deliver comprehensive estimating services for a wide range of construction pro...
Date Posted: 11/04/2025 Recommended
-
Senior Safety Methodology Engineer
Bellevue, WA
Job Title: Senior Safety Methodology Engineer Location: Bellevue, WA Type: Contract Compensation: $67 - $110 hourly Contractor Work Model: Remote About This Opportunity System One is seeking to place a Senior Safety Methodology Engineer with our client...
Date Posted: 01/08/2026 Recommended
-
Structural - Project Engineer
Alexandria, Virginia
Structural Project Engineer Alexandria, VA | Full-Time | Hybrid Work Schedule Available Are you a creative and detail-oriented engineer who enjoys solving complex design challenges? We’re looking for a Structural Project Engineer to join a dynamic, emp...
Date Posted: 12/31/2025 Recommended
-
Associate Scientist
Princeton , NJ
Job Title: Associate Scientist Location: Princeton, NJ Type: Contract Compensation: $30 - $40 hourly Hours: Monday - Friday 8:30 AM - 4:30 PM Responsibilities: Create and test prototypes in the lab with minimal supervision. Perform competitive products...
Date Posted: 01/07/2026 Recommended
-
Fluid Systems Design Engineer
Bellevue, WA
Job Title: Fluid Systems Design Engineer Type: Contract (12 months) Compensation: $52 - $85 hourly Contractor Work Model: Remote System One is seeking a highly capable and motivated System Design Engineer – Fluid Systems to support advanced nuclear and...
Date Posted: 01/09/2026 Recommended
-
Simulator Engineer
Corvillas, OR
Simulator Engineer – Direct Hire Opportunity Corvallis, OR (Preferred) | Remote Options Considered System One is seeking a skilled Simulator Engineer for a direct hire opportunity supporting a client in the nuclear industry. The ideal candidate will he...
Date Posted: 12/09/2025 Recommended
-
Reactor Engineer
Jenkinsville, South Carolina
Company: System One Location: Jenkinsville, SC 29065 Work Environment: Onsite – Nuclear Power Plant Employment Type: Direct Hire, Full-Time Relocation Assistance: Available Engineer, Senior Engineer, or Staff Engineer – Reactor Engineering System One i...
Date Posted: 01/08/2026 Recommended
-
Senior Project Engineer - Roadway
Cranberry Township , Pennsylvania
Job Title: Senior Roadway Project Manager – Licensed PE Location: Pittsburgh, PA Job Type: Full-Time Job Description: We are seeking a highly experienced Roadway Project Manager with 20+ years of proven success in transportation and highway engineering...
Date Posted: 12/31/2025 Recommended
-
Overhead Transmission Engineer III
Syracuse, New York
Job Title: Overhead Transmission Engineer Location: Syracuse, NY About the Role We are seeking a motivated Overhead Transmission Engineer to support the design and development of overhead transmission systems for power delivery projects. This role offe...
Date Posted: 11/12/2025 Recommended
-
Bridge Section Manager
Albany, New York
Bridge Section Manager Albany, NY We believe in building more than infrastructure—we build solutions that make communities stronger, safer, and more sustainable. From resilient energy systems to safer roads and bridges, our work is rooted in the idea t...
Date Posted: 11/12/2025 Recommended
-
Senior Structural Bridge Engineer
Columbia, South Carolina
Senior Structural Bridge Engineer Location: Columbia, SC Company: System One Employment Type: Full-Time | Engineering System One is seeking a Senior Structural Bridge Engineer to join a high-performing transportation design team in Columbia, SC. This i...
Date Posted: 01/14/2026 Recommended