Principal Investigator (MD/DO)
Columbus, Ohio
Experience: 0
Category: Scientific & Clinical
Contractor Work Model: Onsite
Brand: System One
Job ID: 381992
Date Posted: 10/15/2026
Shortcut: http://jobs.systemone.com/hZocoq
Job Title: Principal Investigator (MD/DO)
Location: Columbus, OH
Work Model: Onsite – onsite
We are seeking a US board certified MD/DO to work as a Principal Investigator to lead clinical trials in Columbus, OH. In this role, you will provide medical oversight, ensure patient safety, and collaborate with study teams and sponsors to drive research excellence. The position offers an onsite work environment with a focus on clinical leadership and data quality. Ideal candidates are licensed physicians with research experience and a strong commitment to advancing medical innovation.
Responsibilities
• Provide medical oversight and clinical leadership for assigned clinical trials, ensuring patient safety and data quality.
• Serve as the study physician, reviewing participant eligibility and providing medical oversight of screening outcomes.
• Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
• Perform or oversee study-specific medical assessments, including histories, physical exams, and endpoint assessments.
• Offer clinical guidance and oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and site staff.
• Act as a resource for study-related medical questions and safety concerns.
• Collaborate with study sponsors, CROs, IRBs, and company leadership throughout each trial.
• Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings.
• Review clinical data such as laboratory results, ECGs, vital signs, and other assessments.
Requirements
• MD or DO with a background in Internal Medicine, Family Medicine, or a Specialist.
• Active, unrestricted Ohio medical license.
• Prior clinical research experience as a Principal Investigator, Sub-Investigator, or other clinical research physician role.
• Board certification.
• DEA registration, if required by study protocols.
System One, and its subsidiaries including Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.
Ref: #568-Clinical
Ref: #568-Clinical
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