Principal Investigator (MD/DO)
Pittsburgh, Pennsylvania
Experience: 0
Category: Scientific & Clinical
Contractor Work Model: Onsite
Brand: System One
Job ID: 381995
Date Posted: 10/15/2026
Shortcut: http://jobs.systemone.com/8x9ePf
Job Title: Principal Investigator (MD/DO)
Location: Pittsburgh, PA
Type: Full-time
Overview
We're seeking an experienced Principal Investigator (MD or DO) to support the growth and development of a new clinical research site. If you have prior experience serving as a Principal Investigator and are interested in expanding access to clinical research opportunities within the Pittsburgh community, we'd welcome the opportunity to connect!
Responsibilities
- Provide medical oversight and clinical leadership for assigned clinical trials, ensuring patient safety and data quality.
- Serve as the study physician, reviewing participant eligibility and providing medical oversight of screening outcomes.
- Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
- Perform or oversee study-specific medical assessments, including histories, physical exams, and endpoint assessments.
- Offer clinical guidance and oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and site staff.
- Collaborate with study sponsors, CROs, IRBs, and company leadership throughout each trial.
- Participate in site initiation visits, monitoring visits, close-out activities, and other study meetings.
- Review clinical data such as laboratory results, ECGs, vital signs, and other assessments.
- Support timely safety reporting, medical documentation, and resolution of clinical data queries.
- Maintain compliance with study protocols, SOPs, ICH-GCP, FDA regulations, and state requirements.
- Contribute to a culture of quality, continuous improvement, and patient-centered research.
Requirements
- MD or DO with a background in Internal Medicine, Family Medicine, or a Specialist.
- Active, unrestricted Pennsylvania medical license.
- Prior clinical research experience as a Principal Investigator, Sub-Investigator, or other clinical research physician.
- Strong clinical judgment and commitment to participant safety.
- Interest in clinical research and advancing medical innovation.
- Ability to review structured clinical data and study-specific medical information.
- Strong communication, documentation, and confidentiality practices.
- Familiarity with ICH-GCP and FDA clinical research regulations.
- Board certification.
- DEA registration, if required by study protocols.
System One, and its subsidiaries including Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.
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Ref: #568-Clinical
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