Job Title: Postdoctoral Associate, Human Intestinal Models and Oral Delivery Modeling
Location: Onsite, Pittsburgh, PA 15213
Type: Direct-Hire/Permanent
Hours: Standard business hours
Start: May
Overview: We are looking for a highly motivated Postdoctoral Associate to join a lab focused on discovering novel therapeutics. This interdisciplinary program develops advanced in vitro models of hematopoietic and immune system function such as conducting research at the intersection of microphysiological systems (Organs-on-Chips) and immunology. The role emphasizes the use of intestine-based and interconnected microphysiological systems to model oral delivery, absorption, and systemic distribution of therapeutic agents under physiologically relevant conditions, with integration into multi-organ platforms to enable pharmacokinetic and pharmacodynamic (PK/PD) analyses.

Responsibilities:

• Establish and maintain intestine-based Organs-on-Chips using primary or relevant epithelial cell systems
• Design and execute studies evaluating oral delivery, absorption, and transport of therapeutic agents under controlled experimental conditions
• Perform and optimize assays to assess epithelial barrier function, transport dynamics, and tissue responses
• Support multi-organ integration studies to enable PK/PD analyses across interconnected in vitro systems
• Contribute to development and refinement of experimental workflows to enhance reproducibility and physiological relevance
• Collaborate with multidisciplinary teams to integrate intestinal data with complementary organ systems and analytical platforms
• Support data generation, analysis, and interpretation, including integration of findings across studies
• Maintain accurate and detailed documentation of experimental procedures and results
• Contribute to preparation of manuscripts, reports, and grant applications
• Mentor trainees and assist in training of laboratory personnel as needed

Requirements:

• Ph.D. in Pharmacology, Biomedical Engineering, Physiology, or a related field
• Experience with human intestinal cells and models, and/or intestinal transport biology
• Strong background in experimental design and quantitative analysis
• Strong analytical, organizational, and problem-solving skills
• Ability to work independently and collaboratively in a multidisciplinary research environment
• Strong written and verbal communication skills

• Experience with intestinal models, barrier function assays, or drug absorption studies
• Familiarity with pharmacokinetic/pharmacodynamic (PK/PD) concepts
• Experience with Organs-on-Chips or integrated tissue models
• Experience working in interdisciplinary teams integrating biology, engineering, and pharmacology

#M3
Ref: #558-Scientific